No, once you use the coupon on a single purchase it's gone baby gone forever.
But if you asking can you use more than one coupon on a single purchase, the answer is yes if the products are allowed on that/those coupons.
I just did that with a $25 'thank you" coupon from a previous purchase and the today $25 HOLIDAYS2021 coupon. That's how I got the $75 item for $24.