if you're only using a single instrument on the laptop you could get away with the onboard realtek soundchip and savihost, i know i have, but no clue as to Vocalo Changer performance/requirements etc
/goodluck & have fun
ableton live is currently the most screenreader compatible daw https://help.ableton.com/hc/en-us/articles/11762577169948-Accessibility-in-Ableton-Live-FAQ