What I see when I switch between devices on the same PC (MOTU in ASIO and my HDMI in WASAPI) is that if I have the hardware output set to the second output on the MOTU, save and re-open in WASAPI mode, then since there is only one hardware output on the HDMI, 2 doesn't map to anything, so the output is set to -- Nothing --. It's irritating, and I've been bitten by it a few times in the past.