I had the same problem for the past couple of months with the same interface as yours(Presonus FireStudio Project). I couldn't do much because I was busy with sessions and was afraid of messing everything up, but I did do a lot of the stuff folks posted on here and other sites. After searching the web and this forum I still like you couldn't figure it out and was in the mindset that it had to be the drivers for my interface, but then I recalled that it started right after I installed a new camera and streaming software for my recording studio's website(because of covid I was going to do a lot over the web). So, I went into my Windows10 Settings/System/Sound/Manage Sound Devices and from there I seen that the streaming software I had installed a few months back was enabled on both input and output, So I disabled them and closed out of my settings and opened up Cakewalk and opened up a session and it worked just fine(Didn't have to fight with adjusting the buffet size a hundred times to get it to work right) and of course it started doing the same thing again a few days late, So at this point I'm just going to have to deal with it until there is a fix....