rsinger

Try Blue Cat's Connector - https://www.bluecataudio.com/Products/Product_Connector/

I've upgraded a laptop and DAW. On both machines I had to disable Allow the computer to turn off this device to save power in device manager -> USB controllers -> ... -> Power Management after the upgrade. Only matters if you have a USB IF.

nevermind ...

MeldaProduction has MOscillator - https://www.meldaproduction.com/MOscillator It's part of their free fx bundle. There's a sale on if you want to get rid of the old nag ...

Have you tried both plugged into the same socket or using a surge protector or extension cord with multiple outlets? That should solve a ground loop.

ASIO only supports a single driver, unless a manufacturer designs it for multiples. Uncheck ASIO4ALL and you should be able to select UAD.

Have you optimized the computer for audio? https://www.sweetwater.com/sweetcare/articles/pc-optimization-guide-for-windows-10/

Disable the 2i2 monitor and do you hear the guitar thru TH3 when you play? Are you using an amp or fx? Is the amp or fx turned on? Is TH3 bypassed?

Fripp and Eno used a lot of delay. Originally two tape decks spooled together. Many repeats. If you have delays with long delay times you have a start. Seven to ten seconds of delay time. I like Boz's Imperial Delay. If you don't have it, it's likely on sale. And long (ambient) reverb. A volume pedal or synth patches that swell. Melda's SuperLooper is nice for ambient stuff. Play sound on sound. I'm not familiar with Biosphere.

It takes time to get a signal from the audio inface into the computer and the DAW. Latency is affected by your audio interface, the drivers it uses, your computer and the software and services running on your computer as well as fx in the DAW. With an average IF with an ASIO driver and a decent computer a person can monitor what is recorded in 8-10 ms which is like standing 10 feet away from an amp or monitor.

I picked up the ruby and dream. Those are nice emulations. Now I'm going to get gas for a couple pedals!

IIRC the original Sonar came with the SFZ Player and that supported soundfont. I setup my PCs by loading Platinum and then CbB and I have SFZ ...

NP

You need to export the audio. The input signal is recorded dry. If you save that there are no fx, export it to apply fx.

If the bass isn't up front, you can also try pitch shifting the guitar down an octave, use a little chorus and a lot of eq.