Yes it is. So after checking. It seems to be, that you need to install the correct driver for your specific device. In this case for the use of an UR242 Interface via USB on a Windows machine you need the driver from this page https://o.steinberg.net/en/support/downloads_hardware/downloads_ur242.html
It is the Yamaha Steinberg USB Driver V2.0.4 after installing it it worked like a charm, who would have thought...
Hope this helps others, too.