I have a similar setup with MidiSport 2X2 USB midi interface, M-Audio interface, Roland keyboard & Melodyne. In the last week I have developed the same problems of data in measures and whole tracks disappearing, along with Take Lane problems, and I have searched all over the internet for a resolution. It could possibly be a bug from a plugin (a guess). I went to a local tech who said he would have to go deep into the program to find the culprit with a hefty payday, and suggested I go with another program (one he uses). I like Cakewalk by BandLab and prefer to continue using it, but if I can't find a solution I may have to reconsider his suggestion.