In my experience three things can cause a delay in playback: 1.  Lookahead plugins   - any plugin that has to look ahead will cause a delay in playback, as it has to effectively start playing for the lookahead before the audio is actually heard.  Linear Phase EQ's are the most common culprits. 2. The "Always Open All Devices" and "Allow Arm Changes During Playback/Record" settings  "Always Open All Devices" causes all audio devices to be initialized when the engine is started/restarted.
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