If you enable audiosnap and edit a clip's tempo map to sync transients with musical beats, the editing is not saved with the project and when you reopen it, all the work done is lost.
I found this thread in the old forum, where it can be deduced that the bug was reported in 2017, but has not been fixed yet:
http://forum.cakewalk.com/FindPost/3623086
English is not my mother language, so I find it difficult to explain the bug in detail, please read the above thread for a better exp