I have a Motu 24Ao. This is because the PC is mainly used as a Hauptwerk virtual pipe organ. It has lots of speakers. Drivers all work for Hauptwerk and normal PC use - like for Youtube, running in Linux or in Windows 10 .
But since I wrote on this help board I seem to have fixed the problem. Can I remember what I did? I think it was in Edit, preferences, driver mode I change to MME (32 BIT). Suddenly it worked. What I find very difficult is the techno abbreviations people use. For me a computer is a tool to do things with, rather than a toy to play computers at. I still don't know what people mean by 'a door'. I wish there was a gazetteer of abbreviations somewhere, with a short description of what things do. Like 'COMPRESSOR = takes away from the too loud moments and adds to the soft bits.'
JN